Zoho Project free essay sample

Sublimation Printing most of our imprinting onto pieces of clothing is done as sublimation, rather by the ordinary methods for screen-imprinting onto materials. Sublimation is presumably the most precise and most lasting material printing process known to man. In this procedure, the converse of the picture is at first imprinted onto paper, and is from that point moved onto the clear piece of clothing board utilizing a warmth press for this activity. This bears an unquestionably more precise and perpetual final product than what might be accomplished when utilizing the normal screen-printing process. While screen-printing is done onto the texture, sublimation really hues the individual strands involving a given texture. Flashtrans A one of a kind 3M item which is profoundly intelligent and encourages explicit intelligent logo’s and structures to be applied to articles of clothing. This procedure is most appropriate for application onto to less stretchy textures. This procedure is cited for on a for every cm2 premise, regardless of the amount requested. We will compose a custom paper test on Zoho Project or then again any comparable subject explicitly for you Don't WasteYour Time Recruit WRITER Just 13.90/page Subliflock This progressive new (a world first!) process is perfect for the making of identifications, logo’s and impact subtleties, on both Velotex’s, just as on Cannibal Clothing’s, products. Multicolour advanced sublimation subtleties are imprinted onto a â€Å"peach skin† â€type of substrate, which takes into account plotter-cut, identification like external shapes, to be in this manner cut, making molded identifications or logo external shapes that are then warmth moved onto the article of clothing or board. Subliflock might be utilized any place weaving, screen-printing, an identification, or, for instance, colorful striped-trim subtleties are required. As Subliflock is a non-stretchy substrate, is it appropriate for use on stretch textures, in little measurements just, of state up to 5cm x 5cm, though there is no restriction to estimate, when utilized on non-stretchy textures. This procedure is cited for on a for every cm2 premise, regardless of the amount requested. Velostretch This progressive (likewise a world first!) new procedure is perfect for the formation of logo’s and impact subtleties, on both Velotex’s, just as on Cannibal Clothing’s, merchandise. Single-shading logo’s, pictures or striped-trim detail, for instance, are plotter-cut and afterward heat-moved onto the piece of clothing or board. Velostretch might be utilized any place weaving, screen-printing, an identification, or, for instance, striped-trim subtleties are required. As Velostretch is a profoundly stretchy substrate, is it reasonable for use on stretch textures, in any measurements. Veloflex This procedure is perfect for the making of logo’s and impact subtleties, on both Velotex’s, just as on Cannibal Clothing’s, products. Single shading logo’s, pictures or striped-trim detail, for instance, are plotter-cut and afterward heat-moved onto the piece of clothing or board. Veloflex might be utilized any place weaving, screen-printing, an identification, or, for instance, striped-trim subtleties are required. As Veloflex is a non-stretchy substrate, is it reasonable for use on stretch textures, in little measurements just, state of up to 5cm x 5cm, though there is no restriction to estimate, when utilized on non-stretchy textures. This procedure is cited for on a for each cm2 premise, regardless of the amount requested. Reflex This procedure is perfect for the making of logo’s and impact subtleties, on both Velotex’s and Cannibal Clothing’s, merchandise. Exceptionally intelligent logo’s, pictures or striped-trim detail, for instance, are plotter-cut and afterward heat-moved onto the piece of clothing or board. Reflex might be utilized any place weaving, screen-printing, an identification, or, for instance, striped-trim subtleties are required. As Reflex is a non-stretchy substrate, is it appropriate for use on stretch textures, in little measurements just, state of up to 5cm x 5cm, though there is no restriction to estimate, when utilized on non-stretchy textures. Race Numbers The subtleties are carefully sublimated onto these, best quality, UCI-details, fabric, race-numbers.?Race Numbers costs are amount based per number or per pair of numbers.

Eonomic Signals and Cost-Benefit Analysis in Macroeconomics Essay - 1

Eonomic Signals and Cost-Benefit Analysis in Macroeconomics - Essay Example By investigating the financial information and related signs, business examiners can gauge and foresee the future choices and take choices appropriately. Diverse business and monetary examiners look and screen changed financial pointers as per their own prerequisites and requirements. Sorts OF ECONOMIC SIGNALS USED BY ANALYSTS: These signs which are gotten from the financial information can be classified as immediate signs or aberrant signs. The immediate signs are anything but difficult to decipher and relate with the financial condition. While, the aberrant or easygoing signs are utilized by the financial and business examiner so as to foresee the circuitous effect of macroeconomic marker on the monetary condition in future. This distinction of immediate and roundabout signs can be clarified with the assistance of a model. The financial reports about the expanded GDP and development in various items results in straightforwardly impacting the estimation of the cash and the speculato rs thus can make benefits from it. The roundabout signs which can be gotten from the expectations about the expanded GDP and financial development, because of which the merchants of money enjoy purchasing more cash fully expecting future development in the cash worth and making benefits. MACROECONOMIC ANALYSIS OF RETAIL SALES DATA AND INTERPRETATION OF DIRECT AND INDIRECT SIGNALS: The information of retail deals is commonly utilized by various monetary experts so as to anticipate the measure of the individual or shopper utilization on various physical merchandise. Individual utilization is one of the four significant segments of the Gross Domestic Product (GDP) and legitimately mirrors the financial state of any nation. In some cases, monetary experts likewise utilize the information of retail deals instead of the purchaser utilization in the figuring of the Gross Domestic Product (GDP), if real information about buyer utilization isn't accessible (Rogers, 4). Concerning the investi gation of the business conditions, the expansion in the retail deals plainly demonstrates the expansion in the buying intensity of the buyers alongside the expanding request of the physical items. The retailers and makers can take thus foresee that this expansion in the retail deals will at last increment the cost and in light of this the flexibly of the items increments so as to receive more rewards. Every one of these variables will contribute during the time spent financial development and improvement. Then again if the retail deals decline this signals the diminishing in the buying intensity of purchasers, alongside decline in the interest of the items. Which thusly will squeeze the costs and will decrease the gracefully of these items. This overall will hinder the procedure of financial development. Alongside this the information about the retail deals can control the business experts about the changing requests and needs of the customers. QUESTION # 2: HENRY HAZLITT CONCEPT OF COST BENEFIT ANALYSIS IN MACROECNOMICS: Henry Hazlitt has proposed an entirely different thought of financial arrangements and choices. He, after second universal war, introduced in this book ‘Economics in One Lesson’ that the primary idea driving all examinations and hypotheses of economies is that the expert and approach producers should remember the long haul and bigger effects of any economy arrangement and not just the momentary ramifications (Rockwell, 7).

The Canopy Club Live Music On Campus

The Canopy Club Live Music On Campus Just because youre in central Illinois and not a major city like Chicago doesnt mean you cant get a taste of live music like you would get at Lollapalooza, the 4-day summer festival in Grant Park. Illinois is home to The Canopy Club in Urbana, which is just a short walk from the Main Quad. The Canopy Club is a live music venue that attracts local and world famous musicians that everyone recognizesâ€"artists of all genres that range all the way from Ben Folds to Bone Thugz and Harmony. Whatever music genre you are into, The Canopy Club will have performers for you. Its not just musicians that come down to perform at The Canopy Club either. Last November, I had the opportunity to see famous comedian Hannibal Burress come do stand up comedy. The show was announced the night before and my friends and I love watching the show Broad City so we couldnt miss this show. My reaction to seeing Hannibal Burress. Source: Giphy Burress was doing a show in St. Louis and he was going back on his way to Chicago, his hometown but he figured he would do a surprise show in Urbana since it was on the way. Thats another great thing about Champaign-Urbana because its a great central location between St. Louis and Chicago. Last weekend, I saw this amazing cover band from Chicago called Rod Tuffcurls and The Bench Press. They are a popular cover band and they sang everything from Disneys Moana to Taylor Swift. There were hundreds of people singing the songs together and it was such a fun time. Tickets were only $8 too, which isnt surprising for Canopy Club show because its a venue that serves affordable tickets for students like us. Its really a great resource and venue to check out live music. My biggest regret from my college experience will be not going to the Canopy Club enough, so please make sure you take advantage of everything Illinois has to offer! The view of the amazing cover band at Canopy Club. Source: Personal photo Daniel Class of 2018 I’m an Advertising major in the College of Media. I’m from a northwest suburb of Chicago called Buffalo Grove. I chose Illinois because it was the first university in the entire world to offer an Advertising major, which is pretty cool!

Trusting The Fed s Judgement - 1789 Words

Trusting the Fed’s Judgement in 2017 At last month’s Federal Open Market Committee (FOMC) meeting, Chair Yellen expressed her most upbeat assessment about the near-term path for the US economy by claiming that fiscal stimulus was unnecessary to achieve full employment. Accordingly, unemployment is expected by the FOMC to settle below its natural rate this year. Meanwhile, the current underlying sentiment amongst members appears to suggest that the economy can withstand three 25 basis points increases in the federal funds rate in 2017. This view will, however, not necessarily remain static. In December 2015, for example, the mood of the FOMC appeared to support four 25 basis points increases in its policy rate during 2016. The outcome was,†¦show more content†¦Will the Dollar and Financial Conditions Impact US Monetary Policy in 2017? Deteriorating global financial conditions in the immediate aftermath of the Fed’s December 2015 rate hike helped to produce a sizeable sell off in equity markets in January last year, although a sharp decline in China’s foreign exchange reserves was also to blame. The FOMC was widely expected to raise its policy rate again in March 2016, but the volatile events in financial markets consequently forced members, notably Chair Yellen, to embrace a more dovish policy posture which remained intact until last month. In contrast to last year, financial conditions have not tightened significantly since last month’s decision to raise the federal funds rate. This will, therefore, give a green light for the Fed to proceed with interest rate normalisation depending on economic conditions. Thus, financial markets currently have greater faith in the Fed’s economic outlook compared to a year ago. Meanwhile, the dollar exchange rate presents the FOMC with a more intriguin g challenge, namely the risk of significant overshooting to the upside via a combination of an easier fiscal stance and tightening monetary policy. This outcome occurred between 1980 and 1985, and it helped to produce a significant hollowing out of the US manufacturing sector, notably in the Rust Belt, as well as producing large trade deficits. TheShow MoreRelatedKill A Mockingbird By Harper Lee1982 Words   |  8 Pagesolder brother Jem were considered to be at the top of Maycomb’s social caste due to their light complexion, respectable family history, and Atticus’ career as a lawyer, other families were not so lucky. As Jem stated, There s the ordinary kind like us and the neighbors, there s the kind like the Cunninghams out in the woods, the kind like the Ewells down at the dump, and the Negroes. (Harper 259). Though the Cunningham’s were white, which would normally mean superiority in this small town, theirRead MoreExplore the Ways That Writers Use Contrast Within a Character or Between Characters to Interest the Reader or Audience.1878 Words   |  8 Pages the rate-† (1,3) this implies that that’s Shylock’s real reward. But after Jessica elopes with Lorenzo and Shylock is thrown into a state of rage, he decides to act out on his bond as he becomes very selfish and his need for revenge clouds his judgement. Shylock knows that if he does take his bond, and ultimately kill Antonio, it would benefit him greatly in business â€Å" He lends out money gratis and lowers the rate of usance here in Venice†. Once Shakespeare has made it clear to the audienceRead MoreAn Evalution of the Attachment Theory Essay13038 Words   |  53 Pagesknowledge’ and that good use is made of ‘relevant research findings.’ It is a government requirement that social work practice is to be evidence based and applied with the combined use of knowledge from research and finely balanced professional judgement. (DoH 2000:16). In order to put research into context a literature review is often used. Denscombe (2002:56) recognises a literature review as a way of demonstrating’ the relevance of research by showing how it addresses questions that ariseRead MoreBrand Building Blocks96400 Words   |  386 PagesBRAND BUILDING BLOCKS Building Strong Brands: Why Is It Hard? It is not easy to build brands in today s environment. The brand builder who attempts to develop a strong brand is like a golfer playing on a course with heavy roughs, deep sand traps, sharp doglegs, and vast water barriers. It is difficult to score well in such conditions. Substantial pressures and barriers, both internal and external, can inhibit the brand builder. To be able to develop effective brand strategies, it is useful toRead MoreOrganisational Theory230255 Words   |  922 Pagesmanaging, organizing and reflecting on both formal and informal structures, and in this respect you will find this book timely, interesting and valuable. Peter Holdt Christensen, Associate Professor, Copenhagen Business School, Denmark McAuley et al.’s book is thought-provoking, witty and highly relevant for understanding contemporary organizational dilemmas. 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Furthermore, they come to understand that the tools themselves do not provide answers. It is their judgement and interpretation rather than the analysis itself that have to be relied upon for answers to problems. If these lessons are learned in practice in a strategy course, the lenses become a powerful way of relating notions of strategy to the real worldRead MoreContemporary Issues in Management Accounting211377 Words   |  846 Pagesglobal management accounting community. Alnoor Bhimani London School of Economics December 2005 CONTENTS ‘ FOREWORD Anthony Hopwood PREFACE Alnoor Bhimani CONTRIBUTORS 1. New measures in performance management Thomas Ahrens and Christopher S Chapman 2. Contract theory analysis of managerial accounting issues Stanley Baiman 3. Reframing management accounting practice: a diversity of perspectives Jane Baxter and Wai Fong Chua 4. Management accounting and digitization Alnoor Bhimani 5. TheRead Morepaul hoang answers72561 Words   |  291 Pagessuch cases. Since the Answer Book is 178 pages long, colleagues may find the use of ‘short keys’ useful when searching for answers. By pressing the and keys together, you will be prompted by a pop-up menu. Type in the question number or key word(s) you are seeking answers for (e.g. ‘2.8.3’ or ‘Bausch Lomb’) and press and the answers should appear right in front of you! I hope that you and your students will find the answers (and they are only suggested answers at best) useful in the teaching

Beauty and the Beast...of Media - 1237 Words

Beauty and the Beast...of Media Media is everywhere we turn. It’s displayed on billboards, commercials, Facebook, Twitter and Youtube. It influences people to purchase certain things or even vote for a certain presidential candidate. Media tells us who we are and who we should be. Although media has its positive effects, like spreading the latest news quickly, it also has many downfalls for teenagers, specifically teenage girls, who are hounded with a stream of media related to body image. Today most women always feel the need to look in a mirror whenever they see one to fix their hair or makeup, or even compare themselves to an advertisement featuring an unblemished, blonde haired, skinny woman with perfect hair and skin. Every single girl has done this, but how can it possibly be her fault? For so long women have been trained to compare themselves to others. Girls see flashing lights on every corner that scream to them â€Å"they aren’t good enough† or â€Å"skinny enough†. Seeing thos e ads and their negative message that is sent, girls will go to drastic measures to fit themselves into this image of what society calls â€Å"perfection†, but advertisers are not worried about the person who is buying the product, they are just more worried about if they are going to buy it and often look beyond the point that their ads affect the way girls internalize their messages. For many years, mass media has worked hard to compose this ideal image of what a â€Å"perfect girl† should look like.TheShow MoreRelatedThe Female And Female Relationship1140 Words   |  5 PagesSubmitted date: March 10th, 2016 In our modern society, the mass media and popular culture have cooperative relationships between the dominant and subordinate group, thus the media tend to reinforce and highlight the values and images of those who create the messages and own the means of distribution. 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If children are exposed to stereotypical imagesRead MoreEssay on A Comparison of Beauty and the Beast with Toy Story1236 Words   |  5 Pagesof Beauty and the Beast with Toy Story INTRODUCTION Disney is an excellent example of a Media corporation as it is known worldwide, go any where in the world and ask someone about Mickey Mouse or Daffy Duck and they will know that you are talking about Disney. They have a huge range of advertising and merchandise ranging from childrens books and films to holiday resorts and theme parks. The Disney brand appeals to all, children and adults alike. Beauty andRead MoreFemale Characters Of The Movie The Beast 1090 Words   |  5 Pagesindividuality. In fact, these animated movies introduce the concept of male villains, a status that was primarily reserved for evil queens and witches in the previous fairytales. This new portrayal is shown in Beauty The Beast with Gaston being a simple villager with grand ideas of marriage and schemes of beast-killing. 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Development of Anti-Idiotype Vaccine for Human Follicular Lymphoma Free Essays

string(102) " problems exist for ELISA-based detection of the tumor-specific and vaccine-induced humoral response\." Non-Hodgkin’s lymphomas (NHL) constitute a heterogeneous group of malignancies whose incidence has significantly increased in recent decades. In the year 2000, more than 145,000 cases of NHL were diagnosed in developed countries, representing thus the sixth most common cancer occurring among men and the eighth among women. Low-grade B-cell NHLs, in particular, are incurable diseases characterized by relatively slow growth and excellent initial responsiveness to chemotherapy but also by continuous relapses. We will write a custom essay sample on Development of Anti-Idiotype Vaccine for Human Follicular Lymphoma or any similar topic only for you Order Now In particular, for patients with follicular lymphoma, median overall survival (7-10 years) has not improved over the past 30 years. Although in the vast majority of patients complete or partial remissions can be obtained with either single agents or combination chemotherapy, the clinical course is characterized by a high relapse rate. After relapse, both the response rate and relapse-free survival after subsequent salvage treatment regimens steadily decrease, resulting in a median survival of only 4-5 years after the first relapse. These clinical findings, coupled with the substantial toxicities of standard treatments, have stimulated the search for novel and more tumor-selective therapies. Follicular lymphoma is a clonal B cell malignancy that expresses a unique antigen that is formed by the immunoglobulin light and heavy chains that possess highly variable regions at their amino termini. These variable regions combine to form the antigen recognition site, which can itself be recognized as an antigen, termed the idiotype. The antigen-binding site is a structural feature of each immunoglobulin that distinguishes it from other immunoglobulins. The idiotype of a particular clonal B cell lymphoma represents a tumor-specific antigen. Idiotype is a target of interest in human lymphoma. Therapeutic vaccines targeting B cell lymphoma idiotype (Id) represent a promising immunotherapeutic approach for a better clinical control of these malignancies. Immunoglobulin (Ig) molecules are composed of heavy and light chains that possess highly variable regions at their amino termini. B-cell malignancies are clonal proliferations of Ig-producing cells. The idiotypic determinants of the surface Ig can thus serve as a tumor-specific marker for the malignant clone. Indeed, both protein- and dendritic cell-based vaccines that use the patient-specific Id have resulted in clinically significant tumor-specific cellular responses with very little toxicity. A broad use of Id-based vaccination for B cell lymphomas, however, is hampered by the fact that these approaches are patient-specific so that the vaccine must be individually produced for each patient. On these grounds, new strategies obviating the need to produce customized vaccines would further simplify clinical applications of idiotypic vaccines. Goals: Goal 1: Establishment of a large database including sequences of idiotypic VH and VL genes expressed by a variety of lymphoproliferative disorders, including low grade B-NHL, autoimmunity-associated lymphoproliferations, and chronic lymphocytic leukemia. This will allow the identification of candidate Id proteins for â€Å"cross-reactive† immunotherapy. Goal 2: Pre-clinical characterization of the immunogenicity of selected natural Id proteins, with particular regard to their ability to induce immune responses against lymphoma cells expressing molecularly correlated Id proteins. The characterization will include the identification of B cell epitopes and HLA Class I-restricted cytotoxic T cell epitopes using innovative approaches and will allow the development of dedicated assays for immunomonitoring. Goal 3: Design and validation of optimized Id vaccine. Goal 4: Evaluation and validation of new adjuvants and innovative delivery systems for improved Id vaccine formulations and administration. Goal 5: â€Å"Clinical-grade† production and purification of optimized Id proteins for patient vaccination. Introduction There are approximately 65,000 new cases of non-Hodgkin’s lymphoma diagnosed each year in the US with a comparable number in Europe. Despite the use of aggressive chemotherapy and recent advances in therapy such as monoclonal antibodies (Rituxan, TM), the disease is almost invariably fatal. Follicular lymphoma (FL) patients, in particular, can have an indolent but ultimately fatal clinical course. The median relapse time for FL patients is three years, with 90% of patients dying of a tumor-related mortality within 7 years of the date of diagnosis. The clinical course is usually characterized by a series of remissions and relapses. Good response rates are seen with treatments such as chemotherapy, radiation, lymphocyte transplantation, and monoclonal antibodies. However, following initial response to treatment, the cancer invariably returns and the majority of patients relapse with resistance to all available therapy. Related B-cell derived neoplasms include multiple myeloma (approx. 15,000 cases/year in the US and chronic lymphocytic leukemia (approx. 10,000 cases/year in the US). Isolation of tumor-specific antigens (TSAs) has been a long sought-after goal for scientists involved in both basic and clinical research. Whereas tumor-associated antigens (TAAs) are localized on both normal and tumor cells, TSA are peculiar to tumor cells. This characteristic makes TSA a very desirable target for immune therapy strategies aiming to spare normal cells, or at least the indispensable ones. As regards effectors mechanisms, although some indirect evidence exists for participation of both natural killer (NK) cells (especially those activated by IL-2, known as lymphokine- activated killer, or LAK cells), and TNF-secreting macrophages in tumor immunity, most interest has been focused on the role of antigen-specific antibodies and T lymphocytes. This is particularly true among scientists developing anti-Id vaccines for human FL, even though no substantial agreement has yet been reached on which of the two main effectors pathways is most important. FL conforms to the general rule that tumors have several mechanisms to escape the attention of the immune system. The risks that Ig somatic hypermutations could result in aminoacid residue replacements leading to substantial changes within the fine immunogenic structure of the Id do not seem to be so relevant. Indeed, no such occurrence has been reported in any of the several dozen patients who have been immunized over the last decade. A much more relevant issue is the very limited ability of FL cells to present their own antigens. Although ontogenetically very close to normal mature B-lymphocytes, with respect to their normal counterparts FL cells are very poor as antigen presenting cells (APCs). This makes it rather difficult to evaluate any vaccine-induced, tumor-specific cytotoxicity even in vitro. On the other hand, no such problems exist for ELISA-based detection of the tumor-specific and vaccine-induced humoral response. You read "Development of Anti-Idiotype Vaccine for Human Follicular Lymphoma" in category "Papers" The first study of anti-Id vaccinations in humans dates only from 1992. Until then, all the work had obviously been confined to animal models. However, the accumulation of experimental data has led to the development of several promising strategies that are currently being investigated in clinical trials. These include the utilization of the Id in the form of a soluble protein or as a DNA sequence, either used to pulse dendritic cells (DCs) or else to be administered in combination with immunologic adjuvants. Soluble protein Id vaccine production is based on a hybridoma technique, which in vitro allows production of exactly the same Ig as that present on the surface of the clonal B cells of FL, or in other words the tumor-specific Id. The suspension of single cells obtained from a biopsy specimen almost invariably contains a residual population of normal B-lymphocytes alongside the tumor cells. Screening of the hybridomas by means of Ig heavy chain CDR3 PCR identification is therefore required in order to make sure that the Ig of the selected hybridoma is truly identical to the tumor- associated one.31 Once the cultured hybridoma has yielded enough purified Id, the TSA needs to be made far more immunogenic than it is in its free form. For this purpose, it may either be conjugated with a highly immunogenic carrier such as keyhole limpet hemocyanin (KLH), or else used to pulse autologous DCs. The association of a soluble protein Id vaccine with immunologic adjuvants monocyte colony-stimulating-has also proved extremely important. Granulocyte factor (GM-CSF) currently seems to be the best such adjuvant both in animal models and humans, probably because of its capacity for local recruitment of DCs in vivo at the site of vaccine injections. This step would appear to be superfluous when autologous DCs are loaded with Id ex vivo and then re-injected into the patient. A completely different alternative approach involves administration of the patients’ Id-encoding DNA sequence. With the rise of molecular technology, such DNA vaccines are beginning to come into their own. For instance, exploitation of appropriate molecular vectors (ie containing both a leader and promoter sequence) for insertion of the nucleotide sequences responsible for biosynthesis of both the Ig heavy and light chains variable regions is now relatively easy. Between the heavy- and light-chains variable regions sequences, an intertwined linker peptide must also be inserted to allow the ultimate Id-containing molecule (scFv) to fold properly. Furthermore, the vaccine can be further strengthened by adding other DNA sequences encoding for immunologic adjuvants or powerful immunogens to the vector. Finally, intramuscular injections allow progressive release of the Id following synthesis by muscular cells. In addition, this administration route seems to be associated with prolonged conservation of the genetic information within the cells without any apparent signs of integration into their genome. Experimental Design Goal 1: Establishment of a large database including sequences of idiotypic VH and VL genes expressed by a variety of lymphoproliferative disorders, including low grade B-NHL, autoimmunity-associated lymphoproliferations, and chronic lymphocytic leukemia. This will allow the identification of candidate Id proteins for â€Å"cross-reactive† immunotherapy. In establishing a database, there will be steps to follow in order to support the evidences claimed. I. Finding the cases and the occurrence of VH and VL in lymphoproliferative disorders in different hospitals and institutions that could provide valuable information for the said disorders. The facts and information should have the confirmed consent of the persons involved. II. Subjecting the cases to thorough analysis to provide the essential information needed in documenting the cases. III.   Testing the subject under the identification of Id proteins. IV. Organizing the information and establishing the database. Methods: Establishing a database to easily organize information and data needed in making the information available readily whenever they will analyze situation in which there is a suspected occurrence of lymphoproliferative disorder. By providing the information needed, they could develop system that would make things easier for them to do actions required in addressing such situation. Primary step is consolidating all the available facts and information provided that they have the consent from the owner of the information. By having the desired facts available for the reorganization of it, they could classify it according to the general category they want to use in creating their database. It could be based on severity of the case or could be base on gender or any factor that could greatly affect the situation. Then, by gathering the information they needed, the analysis of the data should be carefully done for them to eliminate excess and negligible data for an easier organization of the structure of their available resources. By implicating the main thrust of the database to the core concept of having advance cases of NHL, the higher chance they could get the information and the data based on the clinical findings of actual patients and people who suffered from that. By simply opening the way of introducing different vaccines in addressing the situation, they could develop a system of transferring and managing information that could make things easier especially in developing new technology and medicinal advancement in creating a better and more effective ways of treating such disease. By making the information more manageable, they could likely innovate an advance communication that would lead them in establishing better information and data management for the use of the development of vaccines and cures. Since they have the information but they should examine carefully every bit of information that will be a part of their set of data and facts. By looking closely to the subjects result and the specification of the action done, the development of such process in introducing a new finding on the matter should be considered. Since the goal is to establish a database that will focus on the information that could provide the facts needed on the cases diagnosed with a NHL, it is important to screen the cases as important and not negligible for them to be able to use it as a case. At the end of the process, they would go back to their primary goal and that is to establish a functional database that the core information and the key factors are integrated in a way that it would make the processing of facts and vital data would be efficient and effectively handled. Also, it will introduce technology that would compensate the fast rising of development in technological advancement even in the field of medicine. Because there are ready to use valuable information for them to handle and initialize their desired action, they would be able to commend the different opportunities in which they could get specimens and studied it for future discoveries and researches. In all, by their incorporation of the cases of NHL and their desired goal of making the information available for them to be able to easily study and review the situations and cases they previously have for them to execute and evaluate the validity of the existing tests in the current occurrence of the disease in the real place. Goal 2: Pre-clinical characterization of the immunogenicity of selected natural Id proteins, with particular regard to their ability to induce immune responses against lymphoma cells expressing molecularly correlated Id proteins. The characterization will include the identification of B cell epitopes and HLA Class I-restricted cytotoxic T cell epitopes using innovative approaches and will allow the development of dedicated assays for immunomonitoring. In dealing with the pre-classification of the immunogenicity of selected natural Id proteins, the processes involved are: I.   Accumulating soluble proteins to be tested. II. Testing them with hybridoma essential in testing the equivalence of the tumor inducing material that leads to development of the tumor. III.   Inducing the effect of the proteins and identifying its effect on B cells. IV. Using advance technique in analyzing the result and implicating with the use of the modern testing equipment and processes. Accumulation: Testing the proteins for it to be classified will be the first step. From the patients who are suffering from FL, different samples will be getting for the medical technology to be applied. Then by cultivating natural proteins, they will use it to further test the capacity of the natural cell in penetrating and deeply interacting with other Id proteins in the development of resistance to such substance. By eradicating some external factors such as the presence of other organisms, they could screen the protein level for them to be able to produce and test the Id proteins by exposing it to toxoids that could develop resistance on the desired solution. Then, the Id proteins gathered will be stored for further testing. Testing: Then, preparation of the Id protein to be tested will be carefully done in a controlled environment. Since the tumor development can not be detected by the immune system, the development of inducing material will be necessary for them to penetrate the basic defenses of the tumor. By exposing it to NKL, tumor will exhibit a different behavior but will not be extinguished. Since B cells epitope derived multiply myeloma that had been the major cause of the return of the behavior of the tumor cells, the gradual exposing it to be classified by soluble Id proteins will be dedicated. The allowance of certain percent productivity will be the basic goal of the clinical testing for them to be able to derive the pre-classification scheme that will determine substances that induce immunity on certain level with the use of soluble and Id protein present in the environment. Effect and its Identification After the testing had been carefully done, they will examine its effect on various elemental positions by trying the substance on the possible outcome. Then, FL cells will be isolated then proteins will be added to see the effect on the neoplasms produced by B-cells. Since the outcome would produce certain behavior that will exhibit a different expected one, the process will be repeatedly associated with soluble proteins to target the development of TSA since it target tumor cells. Analyzing the Result Then, the result will be analyzed in a way that it consistently produces same output. Then after looking closely and making sure that no other substance induced the effect, the validity of the result will be the next concern in analyzing the data. For it to be valuabe, the result should consist the scientific analysis of the vaccine to be introduced for them to be able to adopt a real one. Goal 3: Design and validation of optimized Id vaccine. Since the protein had been introduced in TSA that would target tumor cells, it is important to develop the next stage wherein it will pay attention to that. Tumor cells, after being extinguished by some other methods, always come back and provide a worse situation that before. It is a common problem of the development of cure because as soon as they introduce stronger antigens and antibiotics, the cells develop stronger immunity to them, making them more powerful and gave them the power to come back and come back whenever they are defeated. The result of the previous testing of the material will be used as the raw data in determining the precise development of the vaccine needed for the tumor cells. Toxoids produced by microorganisms will be introduced to the tumor cells for them to create an astounding reaction with the cells to help the antigens produce a better shield to the tumor cells. They would also address the production of its own immunity by targeting the B cells epitopes produced by the tumor cells for them to be able to weaken the effect of the tumor cells in the body. By simply having the same effect on the cells, they would establish the immunity desired. In addition, since soluble proteins produces amino acid residue, the effect of it to the development of various outgoing tumor cells will be beneficial in the sense that it would catch up the screening proves by a hard core stimulation of heavy chain CDR3 PCR. Then, the use of material that would likely predict the behavior will also introduce for the existing antigen to determine it. Goal 4: Evaluation and validation of new adjuvants and innovative delivery systems for improved Id vaccine formulations and administration. After having the result of the vaccine being tested hand-on on the tumor cells, the activation of the production of antigens will be manipulated for those to be able manage the outcome of the result. By having the systematic chain of micro toxoids that will enter the entire system of the body, they would likely produce different kinds of reactions that would benefit the production of self stimulating antigens. By exposing it to different procedures that would attest the certainty and validity of the desired production, after introducing different sets of toxoids and NK cells, the development of the self inducing multiple protein will help in eradicating the symptoms and the effect of FL. It is known that FL is fatal in terms of its effect on the human entire system. So it is important to devise a precise way of handling and dealing with it for them to be able to have an outer perspective of the natural phenomena. Id proteins will act as binders to the solutions that will be used in strengthening NK cells and TSA to promote the development and inhibit the further production of malignant development of tumor cells. By preventing the further growth of it, they would have larger revenue in which they could satisfy the needs and the improvement for having a stronger antigen. Then, natural growth of TSA will be affected by the inducing of soluble protein to target dendritic cells for them to be able to manifest the basic function of fighting foreign toxins that could affect the development of the tumor as a vital implication of the vaccine. The use of different methods in determining the feasibility of inducing the growth and the development of natural antigens that would be sufficient enough to fight the invading tumor cells will be of great use for them to be able t produce more antigens that will prevent the further worsening of the situation. Validating the use f the vaccine as one of the potential sources of defense against the foreign material invading the system would be beneficial if the could handle the needs of having a more systematized and organized level of founding a solution that would focus on the elimination of cell processes that inhibits the growth of malignant tumor like FL that is fatal to humans. Subjecting enough NK cells to further strengthening process will help them in making the process worthwhile I making a protein Id that would address the situation as founding solution to the antigen development. Goal 5: â€Å"Clinical-grade† production and purification of optimized Id proteins for patient vaccination. After developing the vaccine the process would involve the following: I.   Purifying the Vaccine to be prepared. II.   Final Verification III. Mass Production IV.   Patient Vaccination Purification After devising the vaccine, the next step is purifying it by eliminating microorganisms that would have effects on the vaccine. By continuously subjecting the vaccine into different microorganism killing environment, they would lessen the potential of having such. Radiating and constantly developing processes will be sufficient in terminating such microorganisms. Final Verification After the purification of the vaccine, a method will be done for them o be able to test if the results are really valid by having it tested for final verification. It is important to deal with it because the importance f verifying the vaccine would greatly affects its validity in the medical society. By having it tested trough lab rats or animals that have developed FL tumors; they would be injected with such vaccine for them to see if the previous results will e the same. Mass Production After the verification process, the next process will involve producing the vaccine enough for human consumption. The proteins that deal with the development of TSA would have a various report on it validity and essentialism for them to be able to have a developed system of introducing vaccines. Vaccination After the production and the vaccine is ready to use, it would be given to the patients, as long as it is approved by the medical board, to be sued as vaccine against the development of FL into malignant tumors that endangered the lives of many people. Then, by having the system of production of certain involvement of the NK cells within the hybridoma of dendritic cells, the vaccine will be of much use since it will introduce antigens that will prepare the body for the possible FL development. Since there are certain kinds of toxoids that will be introduced, there will be a harsh reaction at first to the place where it is injected because of the behavior of the toxoids and the T cells of the body. This is a sign that the vaccine is effective and doing a reaction that would strengthen the immune system of the body. Discussion After the development of the vaccine in FL, it is important to understand the need of developing such because of its adverse effect on the development of humans. It endangered the lives of many people without having the prior notification of the said disease. This is a vital step in the clinical world. Considering the existence of the natural antigens present in the environment, by the use of Id proteins that inhibits the growth of tumor cells; it would be beneficial to mankind if the continuous development will take place. By exploring the kind of the interaction ventured in this kind of process, the elemental composition of the vaccine would be developed to address the needs of the people in having the desired implication of the subject process. The processing of vaccine would include the development of stages in which it would acknowledge the presence of the cells responsible for the development of the disease. In effect, they would have a better understanding on the subject, matter and would increase the possibility of having a curable state. By implicating the notion of having a different technique in addressing the development of the vaccine, the question left for it is how long would it last for them not only to develop vaccine but also to develop a cure that would forever block the negative effects of the disease. By using and ensuring the safety of the user, they would have a proper citation of the needed plan for them to be able to execute the importance of the vaccine and its use in the modern life. Furthermore, by examining the application of the vaccine in the curing of the disease, we would see the importance of development and use of innovating techniques in determining the possible outcome of the curing of the disease. Finally, the consideration of the process if it fits the standards of the medical consideration despite the fact that there exist different processes that involve much medicinal advancement should take into consideration the impact of the introduction of this vaccine prior to the ethical understanding of the matter.   Since FL can be considered as one of the deadliest disease that one can have, the help of having a vaccine against it is beneficial to the human industry. How to cite Development of Anti-Idiotype Vaccine for Human Follicular Lymphoma, Papers

Physics lab Essay Example For Students

Physics lab Essay Buoyancy occurs because the hot air has a lower density than the cooler outside air. This lower density air weighs less than the air it replaces and that preference is the buoyancy. 2. What makes balloons float when they are full of air but not float when they are deflated? Balloons float when they are full of hot air because the hot air weighs less than the air that is in the chamber which results in a floating balloon. 3. Starting with a hot air balloon, figure out how to make the balloon float. This leaves a dot on the tape for every hit. The power source ensures that the vibration of the stylus will be regular. The period(T) of the timer it takes for the stylus to move all the way down and then up-one complete cycle. The frequency(f) of the timer is how many times the stylus goes through a cycle in a second. So the frequency. We will calculate the frequency using formula Frequency(f)=number of dots/ time, and then calculate the period using formula Period(T)= per unit time/ frequency. Procedure: 1 . Follow instructions and assemble the apparatus. . Put a carbon paper disc which is carbon-side-up on the fix shaft between the attest. 2. Place a short strip of timer tape in the recording timer over the paper disc. 3. Make sure the tape is threaded through the gates and is free of snags. 4. Turn the timer on and pull the strip through the gates. 5. Make sure you are getting dots on the underside of the tape. 6. Use the test tape to decide on the best speed to pull the tape, so that the dots are easy to read. 7. Place a +1. 5 meter piece of tape in the timer. 8. Pull the tape through a gentle, constant motion with one hand. 9. As you pull, operate the stop-watch with the other hand. The time should be close to 3 seconds. 0. Turn the ticker timer off. 11. Remove the tape and mark on it the exact time it took to run the tape. 12. Count the dots on the tape and calculate the frequency and the period of timer. 13. Re-do the above if the results are not satisfying. 14. Repeat the above for all members of the group. 15. Tabulate everyones results and compute all the results. 16. Enter all data in the table. 17. The paper tape is not straight when pulling so it may resulted in inaccurate number of dots. 3. During the experiment on two occasions the disc would either not imprint anything on to the ticker tape paper if the needle was too high or come off during the experiment as it turns. This resulted in trails having to be repeated and the waste of lab materials to retrieve accurate data. 4. The time we release and pull the tape and the operation of the stop-watch were done by two hands. This created the possibility for the tape to be released slightly before or after the timer was activated. . The ideal time is 3 seconds. However, it is next to impossible to be that exact. Such a synchronization problem can change the records of the number of dots but may not seem drastic since we are focused on the frequency and the period of the ticker timer. Percentage Error: argental error= [experiment value accepted value/ x 100 accepted value error in opened XIII Critical Analysis: This lab shows how we can further get to know a ticker timer by applying the knowledge of frequency and period. .u17ec4114b99dd911282a92b5d86066aa , .u17ec4114b99dd911282a92b5d86066aa .postImageUrl , .u17ec4114b99dd911282a92b5d86066aa .centered-text-area { min-height: 80px; position: relative; } .u17ec4114b99dd911282a92b5d86066aa , .u17ec4114b99dd911282a92b5d86066aa:hover , .u17ec4114b99dd911282a92b5d86066aa:visited , .u17ec4114b99dd911282a92b5d86066aa:active { border:0!important; } .u17ec4114b99dd911282a92b5d86066aa .clearfix:after { content: ""; display: table; clear: both; } .u17ec4114b99dd911282a92b5d86066aa { display: block; transition: background-color 250ms; webkit-transition: background-color 250ms; width: 100%; opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #95A5A6; } .u17ec4114b99dd911282a92b5d86066aa:active , .u17ec4114b99dd911282a92b5d86066aa:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #2C3E50; } .u17ec4114b99dd911282a92b5d86066aa .centered-text-area { width: 100%; position: relative ; } .u17ec4114b99dd911282a92b5d86066aa .ctaText { border-bottom: 0 solid #fff; color: #2980B9; font-size: 16px; font-weight: bold; margin: 0; padding: 0; text-decoration: underline; } .u17ec4114b99dd911282a92b5d86066aa .postTitle { color: #FFFFFF; font-size: 16px; font-weight: 600; margin: 0; padding: 0; width: 100%; } .u17ec4114b99dd911282a92b5d86066aa .ctaButton { background-color: #7F8C8D!important; color: #2980B9; border: none; border-radius: 3px; box-shadow: none; font-size: 14px; font-weight: bold; line-height: 26px; moz-border-radius: 3px; text-align: center; text-decoration: none; text-shadow: none; width: 80px; min-height: 80px; background: url(https://artscolumbia.org/wp-content/plugins/intelly-related-posts/assets/images/simple-arrow.png)no-repeat; position: absolute; right: 0; top: 0; } .u17ec4114b99dd911282a92b5d86066aa:hover .ctaButton { background-color: #34495E!important; } .u17ec4114b99dd911282a92b5d86066aa .centered-text { display: table; height: 80px; padding-left : 18px; top: 0; } .u17ec4114b99dd911282a92b5d86066aa .u17ec4114b99dd911282a92b5d86066aa-content { display: table-cell; margin: 0; padding: 0; padding-right: 108px; position: relative; vertical-align: middle; width: 100%; } .u17ec4114b99dd911282a92b5d86066aa:after { content: ""; display: block; clear: both; } READ: The Crucible: Although Abigail And The Girls Initi EssayThrough the lab, I knew that frequency is the number of occurrences of a repeating event per unit time and the period in seconds, meaning the number of seconds per cycle. The lab worked out well in our group with a percentage of error of less than 2% but I still found some possible improvements that can make the results more accurate: 1. We could try pulling the tape before tarring the ticker timer and the stop watch to eliminate the miscounting of the numbers of dots caused by blotching of dots at the beginning of the tape. 2. Invest in a digital photo gate to eliminate the error caused by stopping and starting the stop watch effectively. 3. We can get a more accurate results by pulling a longer tape for as so that some inevitable errors can be minimized. 4. Pull the tape along the edge of the table to have a better result of dots on the tape. Every experiment has errors, but that doesnt mean we are certain to make mistakes, we should be aware of that something we cannot control should lead to errors, yet we need to endeavor to minimize the errors by some methods. Extension Questions: 1 . Why is it important not to pull the tape too quickly? Firstly, once the tape is run out before 3 seconds, we surely need to re-do the lab, thus it would be a waste of time (shorten time for getting a more perfect result) and experiment materials. Secondly, if the dots are recorded entirely, you would find that the distance between two dots are long and harder for us to count the number of the dots. Thirdly, because of the high pulling speed, the spots on the tape maybe light- Loren, it is more likely for us to ignore some of the dots, which will certainly lead to human errors. 2. Why is it also important not to pull the tape too slowly? Pulling the tape too slowly would make the distance between two dots too short, in extreme cases, the dots may coincide, therefore it is harder for us to get exact number of the dots which furthermore will affect the accuracy of the whole experiment. 3. Does is matter whether the dots are unevenly spaced along the tape? What would that indicate? It does not matter. Since what we need is only the umber of the dots in order to calculate the frequency and the period of the ticker timer, the formula we used would average out the number of the unevenly-spaced dots during per time intervals. Therefore, the distance between any two of them doesnt affect the results. However, it indicates that we didnt pull the tape through a constant motion. 4. Would your results be more accurate if you had drawn a longer piece of tape for 5 seconds? Explain. Synchronization problem as we cannot switch on the ticker timer the same time we start the stop watch, and we cannot switch off the ticker timer the same time we stop he stop watch are inevitable. Thus however long the experiment takes, there should be some errors. Whereas, if the period and frequency are calculated by a larger number of dots and a longer experiment time, the results will be more accurate and minimize the error. In order to achieve this, we could, for example, pull a mm+ piece of tape for as. Relevant research: It is apparent that frequency is equal to the reciprocal of the period f =I/T, so it is an inverse relationship and it is a measure of the periodicity of the function. If the number of counts is not very large, it is more accurate to measure the time interval or a predetermined number of occurrences, rather than the number of occurrences within a specified time.